L-CAM expression in lymph node and liver metastases of colorectal carcinomas.
作者： Anna A. M. Van Der Wurff , Jan-Willem Arends , Edith P. M. Van Der Linden , Joop Ten Kate , Fred T. Bosman
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摘要: L-CAM, also known as E-cadherin, is a cell adhesion molecule expressed on the plasma membranes of epithelial cells at intercellular interface. From in vitro gene transfection experiments idea has been conceived that loss L-CAM expression might be related to invasive capacity well metastatic potential tumour cells. In several tumours relation between grade differentiation and noticed: appears associated with immunoreactivity. Also, lymph node metastases poorly differentiated carcinomas was demonstrated. this study we describe lymphogenous haematogenous large bowel adenocarcinomas, using an indirect immunoperoxidase method monoclonal anti-L-CAM antibody 6F9. All studied--lymphogenous haematogenous--demonstrated immunoreactivity pattern comparable primary tumours. Intratumour heterogeneity noted, normal intercellular, apical (non-functional), focally negative areas same tumour. The data indicate their do not differ strikingly expression. This would consistent transient rather than constitutive down-regulation cancer
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