Roles of nucleosides and nucleotide mixture in small bowel transplantation
作者： Keiko Ogita , Sachiyo Suita , Tomoaki Taguchi , Takeshi Yamanouchi , Kouji Masumoto
DOI: 10.1016/S0899-9007(01)00744-4
关键词:
摘要: Abstract Objectives: We investigated the effect of nucleosides (NSs) and nucleotides (NTs) on intestine intestinal graft in a model syngenic small bowel transplantation, with fetal rat as graft. Methods: Two-centimeter jejunal segments from Lewis rats at 19 d gestation were transplanted into abdominal walls 5-wk-old by using non-vascular anastomotic technique. After assigned to one two groups: group 1 did not receive NS or NT 2 was supplemented NT. The grafts recipients examined morphologically 14 after transplantation according conventional histologic immunohistochemical studies neurons smooth muscles. Results: Group gained little body weight, even though both groups received similar amounts food. showed poor development length, diameter, wet weight. They also villi development, abnormalities nerve distribution, degeneration muscle layer structure studies. Conclusions: found that are essential nutrients for growth maintenance structures transplantation.
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