Tolerance to Daytime Sedative Effects of H1 Antihistamines

摘要: Sedation is the principal side effect of first generation H1 antihistamines, and recent studies have suggested that this should limit clinical application these drugs. The sedative also underlies use first-generation drugs as nonprescriptive remedies for insomnia. In both cases, potential tolerance to an important issue which there are few objective data. study reported here, 15 healthy men age 18 50 years received either diphenhydramine mg or placebo twice a day 4 days in randomized, double-blind, crossover trial design. Dependent measures included subjective assessments sleepiness computer-based tests psychomotor performance. Both showed significantly higher levels on 1 compared placebo. By 4, however, were indistinguishable from Similarly, produced significant impairment performance was completely reversed by 4. These data provide confirmation develops prototypical antihistamine, diphenhydramine. On dosing regimen, complete end 3 administration. While other antihistamines regimens may differ, results suggest sedation with remarkable rapidity.