Presence and role of cytosine methylation in DNA viruses of animals
作者： K. Hoelzer , L. A. Shackelton , C. R. Parrish
DOI: 10.1093/NAR/GKN121
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摘要: Nucleotide composition varies greatly among DNA viruses of animals, yet the evolutionary pressures and biological mechanisms driving these patterns are unclear. One most striking discrepancies lies in frequency CpG (the dinucleotide CG, linked by a phosphate group), which is underrepresented small (those with genomes below 10 kb) but not larger viruses. Cytosine methylation might be partially responsible, research on this topic has focused few virus groups. For several that integrate their genome into host genome, status during stage been studied extensively, relationship between viral-induced tumor formation examined carefully. However, for actively replicating viruses—particularly viruses—the motifs rarely known effects viral life cycle obscure. In vertebrate genomes, cytosines at sites methylated, vertebrates acts to regulate gene expression facilitates recognition unmethylated, potentially pathogen-associated DNA. Here we briefly introduce cytosine before reviewing what currently about
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