Emergence of multidrug-resistant Salmonella Gloucester and Salmonella typhimurium in Bangladesh.

摘要: Infections due to non-typhoid Salmonella , resistant antibiotics, have recently emerged as an important health problem worldwide. Antibiotic resistance was studied by the disc-diffusion method among 3,876 (2.78%) isolates cultured from 139,279 faecal samples in a diarrhoea treatment centre Dhaka, Bangladesh, during 1989-1996. Of 499 salmonellae isolated 1989, serogroup C (1.12%) most common, followed Typhi (0.72 %) and B (0.71%). Isolation rate of increasedsignificantlyto2.18%(p<0.01) 1992 compared 0.56% 1991, 2.86% 1995, 2.48% 1996. Serotyping 194 revealed Typhimurium (52%) Gloucester (45%) predominant serotypes. Resistance ampicillin (A), chloramphenicol (C), trimethoprim-sulphamethoxazole (Sxt) (R type-ACSxt) increased 89-100% 1992-1996 from20-28%during1989-1991(p<0.01) S . isolates. In 1993, 8-10% strains both serotypes, ampicillin, chloramphenicol, trimethoprim-sulphamethoxazole, acquired ceftriaxone (Cr) type-ACSxtCr), which to85-92%in1996(p<0.01). All were susceptible ciprofloxacin. A 157-kb conjugative plasmid transferred R type-ACSxt serotypes Escherichia coli K-12. The findings study suggest emergence multidrug-resistant S. for first time significant surveillance is essential monitor identify its sources modes transmission. Key words : ; infections; Gloucester; Typhimurium; Drug resistance, Microbial; resistance; Plasmid; Bangladesh