Prevalence of XMRV nucleic acid and antibody in HIV-1-Infected men and in men at risk for HIV-1 Infection.

摘要: Xenotropic MLV-Related Virus (XMRV) was recently reported to be associated with prostate cancer and chronic fatigue syndrome (CFS). Infection also in 3.7% of healthy individuals. These highly frequencies infection prompted concerns about the possibility a new, widespread retroviral epidemic. The Multicenter AIDS Cohort Study (MACS) provides an opportunity assess prevalence XMRV its association HIV-1 among men who have sex men. Reliable detection requires application multiple diagnostic methods, including human antibodies nucleic acid. We, therefore, tested 332 patient plasma PBMC samples obtained from recent visits subset patients MACS cohort for using Abbott prototype ARCHITECT chemiluminescent immunoassays (CMIAs) RNA proviral DNA single-copy qPCR assay (X-SCA). Although 9 (2.7%) showed low positive reactivity against single antigen CMIA, none these or matched controls were by X-SCA. Thus, we found no evidence regardless serostatus.