Iron acquisition in the cystic fibrosis lung and potential for novel therapeutic strategies.

摘要: Iron acquisition is vital to microbial survival and implicated in the virulence of many pathogens that reside cystic fibrosis (CF) lung. The multifaceted nature iron by both bacterial fungal encompasses a range conserved species-specific mechanisms, including secretion iron-binding siderophores, utilization siderophores from other species, release host proteins haemoproteins, ferrous uptake. Pathogens adapt deploy specific systems depending on availability, bioavailability pool, stage infection presence competing pathogens. Understanding dynamics pathogen has potential unveil new avenues for therapeutic intervention treat acute chronic CF infections. Here, we examine strategies utilized primary acquire discuss different approaches targeting as an antimicrobial strategy.