Benefits of a Synbiotic Formula (Synbiotic 2000Forte ® ) in Critically Ill Trauma Patients: Early Results of a Randomized Controlled Trial

摘要: Since probiotics are considered to exert beneficial health effects by enhancing the host’s immune response, we investigated benefits of a synbiotics treatment on rate infections, systemic inflammatory response syndrome (SIRS), severe sepsis, and mortality in critically ill, mechanically ventilated, multiple trauma patients. Length stay intensive care unit (ICU) number days under mechanical ventilation were also evaluated. Sixty-five patients randomized receive once daily for 15 synbiotic formula (Synbiotic 2000Forte, Medipharm, Sweden) or maltodextrin as placebo. The preparation consisted combination four (1011 CFU each): Pediococcus pentosaceus 5–33:3, Leuconostoc mesenteroides 32–77:1, L. paracasei ssp. 19; L. plantarum 2,362; inulin, oat bran, pectin, resistant starch prebiotics. Infections, septic complications, mortality, ventilatory support, ICU recorded. Synbiotic-treated exhibited significantly reduced infections (P = 0.01), SIRS, sepsis 0.02), mortality. Days 0.01) relation placebo 0.001). administration this seems respect infection rates improve patient’s thus reducing duration support treatment.