作者: Kristian Peters , Anja Worrich , Alexander Weinhold , Oliver Alka , Gerd Balcke
DOI: 10.3390/IJMS19051385
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摘要: The relatively new research discipline of Eco-Metabolomics is the application metabolomics techniques to ecology with aim characterise biochemical interactions organisms across different spatial and temporal scales. Metabolomics an untargeted approach measure many thousands metabolites in species, including plants animals. Changes metabolite concentrations can provide mechanistic evidence for processes that are relevant at ecological These include physiological, phenotypic morphological responses communities environmental changes also other organisms. Traditionally, biochemistry comes from two directions performed distinct spatiotemporal Biochemical studies most often focus on intrinsic individuals physiological cellular Generally, they take a bottom-up scaling up spatiotemporally fine coarser Ecological usually extrinsic acting upon population community scales typically study top-down combination. transdisciplinary links connects In this review, we approaches chemical various levels, mainly plant–organismal interactions, discuss related examples domains. We present recent developments highlight advancements over last decade angles. further address five key challenges: (1) complex experimental designs large variation profiles; (2) feature extraction; (3) identification; (4) statistical analyses; (5) bioinformatics software tools workflows. presented solutions these challenges will advance connecting bridging ecology.