Osteonecrosis in HIV: A case-control study

摘要: Background: Osteonecrosis (avascular necrosis) has been infrequently reported in HIV-infected patients. It is not known whether HIV itself an independent risk factor for osteonecrosis. Methods: We identified 25 patients with osteonecrosis from 1984 to 1999 a large county teaching hospital and two practices Dallas County that specialize HIV-disease related therapy. A retrospective chart review was performed evaluate potential factors Each case matched controls positive status date of diagnosis. Results: In the study, 22 (88%) had at least one compared 24 50 (48%) controls, p = .003. The most common were hyperlipidemia (32%), alcoholism (28%), pancreatitis (16%), corticosteroids (12%), hypercoaguability (12%). Of cases, 12% idiopathic. Multiple joints involved 72% cases. Four none received megesterol acetate before diagnosis osteonecrosis, .01. No significant differences found between cases respect liver function tests, testosterone levels, triglyceride cholesterol or CD4 cell counts. Saquinavir independently associated <.05. However, no overall use protease inhibitors among noted: 79% versus 76%, respectively. Conclusions: increased incidence HIV/AIDS may be due frequency previously such as hyperlipidemia, corticosteroid use, alcohol abuse, hypercoaguability. Use