Matrix tablets based on carrageenans with dual controlled release of doxazosin mesylate.
作者： Matej Pavli , Franc Vrečer , Saša Baumgartner
DOI: 10.1016/J.IJPHARM.2010.08.021
关键词:
摘要: Abstract The use of polymeric polyelectrolytes as matrix-forming agents is far from optimally or fully understood. Polyelectrolyte carrageenan (CARR) matrices loaded with oppositely charged active substance doxazosin mesylate (DM) were investigated according to their water-uptake/erosion properties, in situ complexation ability CARR DM, and the possibility achieve dual drug release control. Interactions between different types (ι-, κ-, λ-) DM confirmed by differential scanning calorimetry (DSC), electron microscopy (SEM), zeta potential measurements. Combination prolonged for more than 24 h. rate order was accordance number ester sulfate moieties per disaccharide unit CARRs (κ (1) > ι (2) > λ (3)). higher charge on backbone, interactions slower release. Low pH, vigorous hydrodynamics, ionic strength resulted faster Based measurements CARRs, proposed influence counterion condensation its effect screening polyelectrolyte–drug lower DM–CARR complexation. Dual control polyelectrolyte offers many new approaches designing controlled-release systems.
elsevier.com
sci-hub.se 参考文章(37)
Saša Baumgartner, Julijana Kristl, Nicholas A. Peppas, Network structure of cellulose ethers used in pharmaceutical applications during swelling and at equilibrium. Pharmaceutical Research. ,vol. 19, pp. 1084- 1090 ,(2002) , 10.1023/A:1019891105250
F. Giordano, A. Rossi, R. Bettini, A. Savioli, A. Gazzaniga, Cs. Novák, Thermal behavior of paracetamol-polymeric excipients mixtures Journal of Thermal Analysis and Calorimetry. ,vol. 68, pp. 575- 590 ,(2002) , 10.1023/A:1016004206043
Satish Kumar Singh, Ninus Caram-Lelham, Thermodynamics of κ-Carrageenan–Amphiphilic Drug Interaction as Influenced by Specific Counterions and Temperature: A Microcalorimetric and Viscometric Study☆ joint international conference on information sciences. ,vol. 203, pp. 430- 446 ,(1998) , 10.1006/JCIS.1998.5502
M.R. Mangione, D. Giacomazza, D. Bulone, V. Martorana, G. Cavallaro, P.L. San Biagio, K(+) and Na(+) effects on the gelation properties of kappa-Carrageenan. Biophysical Chemistry. ,vol. 113, pp. 129- 135 ,(2005) , 10.1016/J.BPC.2004.08.005
H. Omidian, K. Park, Swelling agents and devices in oral drug delivery Journal of Drug Delivery Science and Technology. ,vol. 18, pp. 83- 93 ,(2008) , 10.1016/S1773-2247(08)50016-5
Gemma K. Kinsella, Graeme W. Watson, Isabel Rozas, Theoretical proton affinities of α1 adrenoceptor ligands Bioorganic & Medicinal Chemistry. ,vol. 14, pp. 1580- 1587 ,(2006) , 10.1016/J.BMC.2005.10.007
Angel V Delgado, Fernando González-Caballero, RJ Hunter, Luuk K Koopal, J Lyklema, None, Measurement and Interpretation of Electrokinetic Phenomena (IUPAC Technical Report) Pure and Applied Chemistry. ,vol. 77, pp. 1753- 1805 ,(2005) , 10.1351/PAC200577101753
Madhusudan Hariharan, Thomas A. Wheatley, James C. Price, Controlled-Release Tablet Matrices from Carrageenans: Compression and Dissolution Studies Pharmaceutical Development and Technology. ,vol. 2, pp. 383- 393 ,(1997) , 10.3109/10837459709022637
Andreas M. Hugerth, Micropolarity and Microviscosity of Amitriptyline and Dextran Sulfate/Carrageenan‐Amitriptyline Systems: The Nature of Polyelectrolyte–Drug Complexes Journal of Pharmaceutical Sciences. ,vol. 90, pp. 1665- 1677 ,(2001) , 10.1002/JPS.1117
M.C. Bonferoni, S. Rossi, M. Tamayo, J.L. Pedraz, A. Dominguez-Gil, C. Caramella, On the employment of λ-carrageenan in a matrix system. I. Sensitivity to dissolution medium and comparison with Na carboxymethylcellulose and xanthan gum Journal of Controlled Release. ,vol. 26, pp. 119- 127 ,(1993) , 10.1016/0168-3659(93)90111-H