Optimization of preparation of DHAQ-loaded PEG-PLGA-PEG nonaparticles using central composite design
作者： Yourong Duan , Sen Xu , Qi Wang , Jie Liu , Zhirong Zhang
DOI: 10.1007/S10856-006-8940-4
关键词:
摘要: Mitoxantrone (DHAQ)-loaded poly (ethylene glycol)-poly (lactic acid-co-glycolic acid) –poly (ethyleneglycol) (PELGE) nanoparticles (NP) were fabricated using an emulsification/solvent evaporation technique. A central composite design (CCD) was applied to evaluate the joint influence of three formulation variables: amounts polymer, concentration DHAQ, and ratio organic phase (inner-phase) aqueous (outer-phase). In this study, we optimize preparation technology on basis single factor evaluation. The optimal conditions for DHAQ-loaded nanoparticle found be: PELGE 9 mg/mL, inner-phase DHAQ 27.5 mg/L, inner-phase/outer-phase 8.5/1. results showed that CCD is ideal technique studies. entrapment efficiency (ER) 90% particle sizes are less than 500 nm. nanoparticles, as examined by transmission electron microscopy (TEM), have a smooth spherical surface. could be loaded into copolymers. nanoparticle-polymer delivery system established polymers carrier material.
springer.com
sci-hub.se 参考文章(13)
Sébastien Branchu, Robert T. Forbes, Peter York, Håkan Nyqvist, A central composite design to investigate the thermal stabilization of lysozyme. Pharmaceutical Research. ,vol. 16, pp. 702- 708 ,(1999) , 10.1023/A:1018876625126
You Rong Duan, W.S. Liu, J. Liu, Z.R. Zhang, A Study on PELGE Nanoparticles as Controlled Drug Delivery Systems for Intravenous Key Engineering Materials. pp. 163- 166 ,(2005) , 10.4028/WWW.SCIENTIFIC.NET/KEM.288-289.163
Young-Il Jeong, Chong-Su Cho, Sung-Hyun Kim, Kyung-Soo Ko, Sun-Il Kim, Yong-Ho Shim, Jae-Woon Nah, Preparation of poly(DL‐lactide‐co‐glycolide) nanoparticles without surfactant Journal of Applied Polymer Science. ,vol. 80, pp. 2228- 2236 ,(2001) , 10.1002/APP.1326
Mercè Foradada, Montserrat Gallardo, Joan Estelrich, Design and applications of a new fluorimetric assay of thioguanine in liposomes. Journal of Pharmaceutical and Biomedical Analysis. ,vol. 12, pp. 1495- 1499 ,(1994) , 10.1016/0731-7085(94)00102-2
Khawla A. Abu-Izza, Lucila Garcia-Contreras, D. Robert Lu, Preparation and evaluation of sustained release AZT-loaded microspheres: optimization of the release characteristics using response surface methodology. Journal of Pharmaceutical Sciences. ,vol. 85, pp. 144- 149 ,(1996) , 10.1021/JS950353+
R Gref, Y Minamitake, M. Peracchia, V Trubetskoy, V Torchilin, R Langer, Biodegradable long-circulating polymeric nanospheres Science. ,vol. 263, pp. 1600- 1603 ,(1994) , 10.1126/SCIENCE.8128245
You Rong Duan, Z.R. Zhang, Y. Huang, Chao Yuan Wang, Preparation of Nano-HAp as Vectors for Targeting Delivery System Key Engineering Materials. pp. 887- 890 ,(2003) , 10.4028/WWW.SCIENTIFIC.NET/KEM.254-256.887
K Avgoustakis, A Beletsi, Z Panagi, P Klepetsanis, AG Karydas, DS Ithakissios, PLGA-mPEG nanoparticles of cisplatin: in vitro nanoparticle degradation, in vitro drug release and in vivo drug residence in blood properties. Journal of Controlled Release. ,vol. 79, pp. 123- 135 ,(2002) , 10.1016/S0168-3659(01)00530-2
A.D. McLeod, F.C. Lam, P.K. Gupta, C.T. Hung, Optimized synthesis of polyglutaraldehyde nanoparticles using central composite design. Journal of Pharmaceutical Sciences. ,vol. 77, pp. 704- 710 ,(1988) , 10.1002/JPS.2600770813
Sanford Bolton, Factorial Designs in Pharmaceutical Stability Studies Journal of Pharmaceutical Sciences. ,vol. 72, pp. 362- 366 ,(1983) , 10.1002/JPS.2600720410