Randomized trial of beta-lactam regimens in febrile neutropenic cancer patients

摘要: A three-arm prospective randomized trial was designed to compare the efficacies of piperacillin plus vancomycin, ceftazidime or all three drugs as initial therapy for fever in neutropenic cancer patients. The objectives were determine whether a broad-spectrum penicillin effective cephalosporin and two beta-lactam antibiotics more than one. Four hundred seventy 519 febrile episodes entered study could be evaluated response. Ceftazidime vancomycin significantly considering (79 percent versus 61 percent, p = 0.001), documented infections 57 0.004), gram-negative (88 47 bacteremias (81 51 0.01). addition (piperacillin vancomycin) did not improve response rate associated with higher incidence skin rash. Vancomycin provides adequate antibiotic coverage treatment This combination equally effective, less expensive, toxic double used this study.