Well-differentiated thymic carcinoma. An organotypical low-grade carcinoma with relationship to cortical thymoma.

摘要: Based on a study of 26 cases, the well-differentiated thymic carcinoma is described as distinct organotypical thymus with low-grade malignancy. It characterized by predominance epithelial cells usually low mitotic rate, an epidermoid differentiation slight to moderate cytological atypia, constant presence interepithelial immature cortical thymocytes, lobular growth, and formation palisades around perivascular spaces. The tumor occurs at age 14 76 years in both sexes. An association myasthenia gravis found 77% patients, 83% tumors show invasion adjacent organs or endothoracic metastasis primary operation. This rate higher than thymomas (47%) but lower other carcinomas (92%). Two 18 patients follow-up died recurrence pleural metastasis. Well-differentiated can be related thymoma common morphological features similar immunophenotype cells. must differentiated from lymphocyte-depleted after corticosteroid treatment benign epithelial-rich medullary thymomas.