Localization of PDGF-B protein in macrophages in all phases of atherogenesis.
作者： R Ross , J Masuda , E. Raines , A. Gown , S Katsuda
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摘要: Lesions of atherosclerosis occur in the innermost layer artery wall and consist primarily proliferated smooth muscle cells surrounded by large amounts connective tissue, numerous lipid-laden macrophages, varying numbers lymphocytes. Growth-regulatory molecules may be involved intimal accumulation proliferation responsible for occlusive lesions atherosclerosis. Platelet-derived growth factor (PDGF) B-chain protein was found within macrophages all stages lesion development both human nonhuman primate Thus play a critical role disease providing PDGF, potent chemotactic growth-stimulatory molecule, to cells.
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