Genetic Polymorphisms and Recurrent Spontaneous Abortions: An Overview of Current Knowledge
作者： Silvia Daher , Rosiane Mattar , Bárbara Y. Gueuvoghlanian-Silva , Maria R. Torloni
DOI: 10.1111/J.1600-0897.2012.01123.X
关键词:
摘要: The relevance of gene polymorphisms in the development unexplained recurrent spontaneous abortion is still unclear. Cytokines, angiogenic mediators, and hormones are involved all stages reproduction pregnancy outcome. Impaired production and/or unbalanced ratios these mediators have been implicated pathogenesis abortion. Functional polymorphism influence activity therefore can interfere with expression mediators. Several studies carried out to evaluate relationship between cytokines, results mostly contradictory, few significant associations identified. Up present time, evidence insufficient support evaluation routine workup cases loss, tests not included any major obstetric guidelines.
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