Assessing clinical prospects of silicon quantum dots: studies in mice and monkeys.

摘要: Silicon nanocrystals can provide the outstanding imaging capabilities of toxic heavy-metal-based quantum dots without employing heavy metals and have potential for rapid progression to clinic. Understanding toxicity silicon (SiQDs) is essential realizing this potential. However, existing studies SiQD biocompatibility are limited, with no systematic from small-animal large-animal that more clinically relevant. Here, we test response both mice monkeys high intravenous doses a nanoconstruct created using only SiQDs FDA-approved materials. We show (1) neither nor overt signs reflected in their behavior, body mass, or blood chemistry, even at dose 200 mg/kg. (2) This formulation did not biodegrade as expected. Elevated levels were present liver spleen three months post-treatment. (3) Histopathology after treatment showed adverse effects nanoform...