A new hydrogen peroxide--based medical-device detergent with germicidal properties: comparison with enzymatic cleaners.

摘要: Abstract Background: The objective of this study was to evaluate the efficacy cleaning and bacterial killing ability a new non–enzyme-based formulation (killing detergent solution [KDS]) compared with commercially available enzymatic detergents that included Metrizyme (Metrex Research Division Sybron Canada Ltd. Morrisburg, Ontario) Gzyme (Germiphene Corp, Brantford, Ontario). KDS is hydrogen peroxide–based combines kill microorganisms. helps ensure protection health care worker from infectious risk during soaking stages medical device reprocessing reduces bioburden on devices before sterilization/disinfection. Methods: Test organisms Enterococcus faecalis , Salmonella choleraesuis Staphylococcus aureus Pseudomonas aeruginosa were suspended in artificial test soil (ATS-B; patent submitted), inoculated at 10 6 colonyforming units per carrier dried overnight exposure. ATS-B mimics blood, protein, carbohydrate, endotoxin levels patient-used devices. Plastic lumen carriers flexible colonoscope used for surface simulated-use testing, respectively. Results: results microbial challenge onto polyvinyl chloride (PVC) demonstrated remove as effective enzyme evaluated. Furthermore, able effect approximately 5-Log reduction loads 3-minute exposure room temperature, whereas none other effective. In testing soiled colonoscope, significantly better ensuring equivalent ability. Conclusions: summary has excellent microbial-killing exposures temperature cleans well existing formulations tested. (Am J Infect Control 2001;29:168-77)