Effect of long-term immunosuppression in kidney-graft recipients on cancer incidence: randomised comparison of two cyclosporin regimens

摘要: The introduction of cyclosporin into maintenance therapy for kidney-transplant recipients has played an important part in the improvement graft survival reported worldwide [1]. Cyclosporin is potentially toxic to various tissues including kidney, liver, endocrine pancreas, and nervous system, its use associated with hypertension [2]. Nevertheless, capacity treatment increase been recognised a long time. Optimum doses trough blood concentrations have empirically evolved so as cause least kidney toxicity. However, other potential side-effects related immunosuppressant properties, occurrence infections tumours. magnitude these effects may also vary dose consequent concentrations. Thus, there schedules. In terms reducing long-term complications immunosuppression, such cancers [3], are unlike organ-graft because dialysis viable alternative.