RCT of an integrated CBT-HIV intervention on depressive symptoms and HIV risk.

摘要: Depression and depressive symptoms mediate the association between drug use HIV risk. Yet, there are few interventions that target risk for people who drugs (PWUD). This study was a randomized controlled trial of an integrated cognitive behavioral therapy prevention intervention to reduce symptoms, injection behaviors increase condom in sample urban used heroin or cocaine prior 6 months. A total 315 individuals aged 18-55, self-reported at least one sex behavior scored ≥16 <40 on Centers Epidemiologic Studies-Depression (CES-D) scale were using two-block design, stratified by ensure equivalent numbers, 10 session arm (n = 162) single control 153). The outcomes interest decreases CES-D score increases use. majority African American (85%) unemployed (94%). Nearly half (47%) reported months only 19% taking medication depression. Follow-up assessments conducted 12 Retention 94%. Intervention associated with statistically significantly lower month compared control. No differences observed arms At month, greater odds non-main partner. These findings suggest potential role reducing but weak impact is registered ClinicalTrials.gov under title "Neighborhoods, Networks, Depression, Risk" number NCT01380613.