Connexin36 and pancreatic β-cell functions

摘要: AbstractMost cell types are functionally coupled by connexin (Cx) channels, i.e. exchange cytoplasmic ions and small metabolites through gap junction domains of their membrane. This form direct cell-to-cell communication occurs in all existing animals, whatever position the phylogenetic scale, up to humans. Pancreatic β-cells no exception, normally cross-talk with neighbors via channels made Cx36. These exchanges importantly contribute coordinate synchronize function individual cells within pancreatic islets, particularly context glucose-induced insulin secretion. Compelling evidence now indicates that Cx36-mediated coupling, and/or Cx36 protein per se, play significant regulatory roles various β-cell functions, ranging from biosynthesis, storage release insulin. Recent preliminary data further suggest may also be implicated balance growth versus necrosis apoptosis, regulated express...