Cellular targets of estrogen signaling in regeneration of inner ear sensory epithelia.

摘要: Estrogen signaling in auditory and vestibular sensory epithelia is a newly emerging focus propelled by the role of estrogen many other proliferative systems. Understanding pathways with which interacts can provide means to identify how may modulate inner ear epithelia. Reviewed herein are two families, EGF TGFbeta. Both involved regulating proliferation supporting cells mature have well characterized interactions It becoming increasingly clear that elucidating complexity regeneration will be necessary for development therapeutics initiate prevent progression pathogenic state.