Generating a T cell tumor-specific immune response in vivo: can flt3-ligand-generated dendritic cells tip the balance?
作者： H. J. McKenna
关键词:
摘要: flt3 ligand (FL) is a growth factor that induces hematopoietic progenitor cell and dendritic (DC) expansion when administered to mice. Lymphoid-related (CD8α+) myeloid-related (CD8α−) DC are transiently expanded in multiple tissues. Treatment of tumor-bearing mice with FL results slower tumor and, some cases, rejection the development tumor-specific T immunity. The clinical use as cellular vehicles for antigen presentation generate response under investigation. currently generated ex vivo, pulsed antigen, then infused into patients, much effort being directed toward optimizing each these steps. Administration humans profound increase circulating DC. availability large number vivo has important implications immunotherapy approaches.
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