Mechanisms of cutaneous toxicities to EGFR inhibitors.

摘要: The increased target specificity of epidermal growth factor receptor (EGFR) inhibitors (EGFRIs) is associated with the reduction or abolition nonspecific and haematopoietic side effects. However, coincident inhibition activity in tissues that depend on EGFR signalling for normal function has undesirable consequences. Because key role skin, dermatological toxicities have frequently been described EGFRIs. resultant significant physical psycho-social discomfort might lead to interruption dose modification anticancer agents. There an urgent need improved understanding these develop adequate staging systems mechanistically driven therapies, ensure quality life consistent antineoplastic therapy.