Impact of preoperative thrombocytosis on pathological outcomes and survival in patients treated with radical cystectomy for bladder carcinoma.

摘要: AIM To investigate the impact of preoperative platelet count on pathological findings at time Radical Cystectomy for Bladder Cancer and postoperative cancer-specific overall survival. PATIENTS AND METHODS A total 906 consecutive patients treated with between 1995 2012 a tertiary referral Center were included in study. Thrombocytosis was defined as >400,000 platelets/μl, agreement standard assumed by central laboratory our Institution. Univariable multivariable logistic regression analyses used to stage. Univariate multivariate Cox also adopted predict both RESULTS The mean age cystectomy 67.25 years. median counts 242,100/μl 227,500/μl. At follow-up 41 months, 2- 5-year survival found be 83.1% 75.2% 68.3 59.8%, respectively. analysis, thrombocytosis significantly associated adverse disease stage (p ≤ 0.007) lymph node invasion (p=0.05). Platelet patient univariable analysis (Hazard Ratio=1.76 1.39 cancer specific survival, respectively; all p<0.05). documented related only Ratio=64,1.03-2.81; p=0.05). CONCLUSION Preoperative should taken into account factor predictive oncological outcomes after radical bladder counseled accordingly.