Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement.

作者: J. W. Dalley , T. D. Fryer , L. Brichard , E. S. J. Robinson , D. E. H. Theobald

DOI: 10.1126/SCIENCE.1137073

关键词:

摘要: Stimulant addiction is often linked to excessive risk taking, sensation seeking, and impulsivity, but in ways that are poorly understood. We report here that a form of impulsivity …

参考文章(44)
David E. Comings, Kenneth Blum, Reward deficiency syndrome: genetic aspects of behavioral disorders. Progress in Brain Research. ,vol. 126, pp. 325- 341 ,(2000) , 10.1016/S0079-6123(00)26022-6
S. Barak Caine, S. Stevens Negus, Nancy K. Mello, Smita Patel, Linda Bristow, Janusz Kulagowski, Daniela Vallone, Adolfo Saiardi, Emiliana Borrelli, Role of Dopamine D2-like Receptors in Cocaine Self-Administration: Studies with D2 Receptor Mutant Mice and Novel D2 Receptor Antagonists The Journal of Neuroscience. ,vol. 22, pp. 2977- 2988 ,(2002) , 10.1523/JNEUROSCI.22-07-02977.2002
Jeffrey W. Dalley, Kristjan Lääne, Yolanda Pena, David E. H. Theobald, Barry J. Everitt, Trevor W. Robbins, Attentional and motivational deficits in rats withdrawn from intravenous self-administration of cocaine or heroin Psychopharmacology. ,vol. 182, pp. 579- 587 ,(2005) , 10.1007/S00213-005-0107-3
Hugh O. Pettit, Aaron Ettenberg, Floyd E. Bloom, George F. Koob, Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats Psychopharmacology. ,vol. 84, pp. 167- 173 ,(1984) , 10.1007/BF00427441
Jennifer L. Perry, Erin B. Larson, Jonathan P. German, Gregory J. Madden, Marilyn E. Carroll, Impulsivity (Delay Discounting) as a Predictor of Acquisition of IV Cocaine Self-Administration in Female Rats Psychopharmacology. ,vol. 178, pp. 193- 201 ,(2005) , 10.1007/S00213-004-1994-4
Tracie A. Paine, Hans C. Dringenberg, Mary C. Olmstead, Effects of chronic cocaine on impulsivity: relation to cortical serotonin mechanisms Behavioural Brain Research. ,vol. 147, pp. 135- 147 ,(2003) , 10.1016/S0166-4328(03)00156-6
Karen I. Bolla, Richard Rothman, Jean Lud Cadet, Dose-related neurobehavioral effects of chronic cocaine use. Journal of Neuropsychiatry and Clinical Neurosciences. ,vol. 11, pp. 361- 369 ,(1999) , 10.1176/JNP.11.3.361
Jogeshwar Mukherjee, Zhi-Ying Yang, Terry Brown, Robert Lew, Miles Wernick, Xiaohu Ouyang, Nicholas Yasillo, Chin-Tu Chen, Robert Mintzer, Malcolm Cooper, Preliminary assessment of extrastriatal dopamine D-2 receptor binding in the rodent and nonhuman primate brains using the high affinity radioligand, 18F-fallypride. Nuclear Medicine and Biology. ,vol. 26, pp. 519- 527 ,(1999) , 10.1016/S0969-8051(99)00012-8