Brain Imaging in Addiction

作者: David Nutt , Anne Lingford-Hughes , Liam Nestor

DOI: 10.1016/B978-0-12-385973-0.00001-6

关键词: Resting state fMRINeuroimagingBold fmriAddictionPsychologyOpioidFunctional magnetic resonance imagingCognitionHeroinNeuroscience

摘要: Publisher Summary This chapter focuses on neuroimaging techniques, explaining their relevance to understanding drug addiction. There are two main divisions in techniques: structural and functional. The former measures features of brain structure such as its size, shape, density. Functional magnetic resonance imaging (fMRI) exploits the fact that property blood changes when oxygen is removed. can be detected using an MRI paradigm known BOLD signal. Structural technique volume shape with reasonable precision. It used investigate potential differences brains certain populations. endorphin system major target for opioid drugs morphine heroin. has long been implicated processes interpersonal bonding, love, and, lacking, pain. Drug dependence commonly associated emotional, cognitive, behavioral reactivity drug-related stimuli or images events use.

参考文章(92)
Arthur L Brody, Mark A Mandelkern, Richard E Olmstead, Zoe Allen-Martinez, David Scheibal, Anna L Abrams, Matthew R Costello, Judah Farahi, Sanjaya Saxena, John Monterosso, Edythe D London, Ventral Striatal Dopamine Release in Response to Smoking a Regular vs a Denicotinized Cigarette Neuropsychopharmacology. ,vol. 34, pp. 282- 289 ,(2009) , 10.1038/NPP.2008.87
Hugh Myrick, Raymond F. Anton, Xingbao Li, Scott Henderson, Patrick K. Randall, Konstantin Voronin, Effect of Naltrexone and Ondansetron on Alcohol Cue-Induced Activation of the Ventral Striatum in Alcohol-Dependent People Archives of General Psychiatry. ,vol. 65, pp. 466- 475 ,(2008) , 10.1001/ARCHPSYC.65.4.466
N. D. Volkow, G.-J. Wang, F. Telang, J. S. Fowler, J. Logan, M. Jayne, Y. Ma, K. Pradhan, C. Wong, Profound Decreases in Dopamine Release in Striatum in Detoxified Alcoholics: Possible Orbitofrontal Involvement The Journal of Neuroscience. ,vol. 27, pp. 12700- 12706 ,(2007) , 10.1523/JNEUROSCI.3371-07.2007
Andrew J. Montgomery, Anne R. Lingford-Hughes, Alice Egerton, David J. Nutt, Paul M. Grasby, The effect of nicotine on striatal dopamine release in man: A [11C]raclopride PET study. Synapse. ,vol. 61, pp. 637- 645 ,(2007) , 10.1002/SYN.20419
Kenneth Blum, Eric R. Braverman, Jay M. Holder, Joel F. Lubar, Vincent J. Monastra, David Miller, Judith O. Lubar, Thomas J.H. Chen, David E. Comings, Reward deficiency syndrome: a biogenetic model for the diagnosis and treatment of impulsive, addictive, and compulsive behaviors. Journal of Psychoactive Drugs. ,vol. 32, pp. 1- 112 ,(2000) , 10.1080/02791072.2000.10736099
N D Volkow, J S Fowler, G-J Wang, J M Swanson, Dopamine in drug abuse and addiction: results from imaging studies and treatment implications Molecular Psychiatry. ,vol. 9, pp. 557- 569 ,(2004) , 10.1038/SJ.MP.4001507
J. W. Dalley, T. D. Fryer, L. Brichard, E. S. J. Robinson, D. E. H. Theobald, K. Laane, Y. Pena, E. R. Murphy, Y. Shah, K. Probst, I. Abakumova, F. I. Aigbirhio, H. K. Richards, Y. Hong, J.-C. Baron, B. J. Everitt, T. W. Robbins, Nucleus accumbens D2/3 receptors predict trait impulsivity and cocaine reinforcement. Science. ,vol. 315, pp. 1267- 1270 ,(2007) , 10.1126/SCIENCE.1137073
Steven D Forman, George G Dougherty, B.J Casey, Greg J Siegle, Todd S Braver, Deanna M Barch, V.Andrew Stenger, Charlene Wick-Hull, Liubomir A Pisarov, Emily Lorensen, Opiate addicts lack error-dependent activation of rostral anterior cingulate. Biological Psychiatry. ,vol. 55, pp. 531- 537 ,(2004) , 10.1016/J.BIOPSYCH.2003.09.011
Mira Bühler, Sabine Vollstädt-Klein, Andrea Kobiella, Henning Budde, Laurence J. Reed, Dieter F. Braus, Christian Büchel, Michael N. Smolka, Nicotine Dependence Is Characterized by Disordered Reward Processing in a Network Driving Motivation Biological Psychiatry. ,vol. 67, pp. 745- 752 ,(2010) , 10.1016/J.BIOPSYCH.2009.10.029
Ruben D. Baler, Nora D. Volkow, Drug addiction: the neurobiology of disrupted self-control Trends in Molecular Medicine. ,vol. 12, pp. 559- 566 ,(2006) , 10.1016/J.MOLMED.2006.10.005