Opiate addicts lack error-dependent activation of rostral anterior cingulate.

摘要: Abstract Background Healthy individuals performing response suppression tasks activate anterior cingulate cortex with occurrence of false alarm error responses to nontargets. Fundamental questions include whether this error-related activation provides a signal contributing behavioral control and, given generally poorer performance on such by addicts, is disrupted in addiction. Methods We used rapid, event-related functional magnetic resonance imaging study 13 opiate dependence and 26 healthy Go/NoGo task. Results Compared controls, addicts exhibited an attenuated significantly task performance. In the individual level accompanying positively predicted performance, particularly sensitivity discriminating targets from Conclusions The attenuation may play role loss addiction other forms impulsive behavior.