The handling of glucose and insulin response before and after weight loss with jejuno-ileal bypass: a preliminary report.

作者: Ian Sanderson , Mervyn Deitel , Morris A. Bojm

DOI: 10.1177/0148607183007003274

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摘要: Glucose and insulin response were studied in morbidly obese patients before after jejuno-ileal bypass. Postbypass studies performed weight loss greater than 30% (9-48 mon). Six-hour oral glucose tolerance tests on 33 bypass 13 of these Thirteen had preoperative intravenous performed, 11 postbypass performed. Plasma insulins drawn concomitantly. Before bypass, fasting blood sugars elevated both intolerance hyperinsulinemia found the tests. After test curves flat (malabsorption effect), while revealed nonsignificant changes but plasma returned toward normal (p 0.05). The massively reverted from Thus does not appear to be a primary etiological factor obesity.

参考文章(27)
Morris A. Bojm, Mervyn Deitel, Malabsorption of medications after bypass surgery. Canadian Medical Association Journal. ,vol. 124, pp. 681- 684 ,(1981)
E.A.H. SIMS, E. DANFORTH, E.S. HORTON, G.A. BRAY, J.A. GLENNON, L.B. SALANS, Endocrine and metabolic effects of experimental obesity in man. Recent Progress in Hormone Research. ,vol. 29, pp. 457- 496 ,(1973) , 10.1016/B978-0-12-571129-6.50016-6
Himms-Hagen J, Obesity may be due to a malfunctioning of brown fat Canadian Medical Association Journal. ,vol. 121, pp. 1361- 1364 ,(1979)
C. RONALD KAHN, Receptors for Peptide Hormones Annals of Internal Medicine. ,vol. 86, pp. 205- 219 ,(1977) , 10.7326/0003-4819-86-2-205
Robert R. Wolfe, John R. Allsop, John F. Burke, Glucose metabolism in man: Responses to intravenous glucose infusion Metabolism-clinical and Experimental. ,vol. 28, pp. 210- 220 ,(1979) , 10.1016/0026-0495(79)90066-0
Jerome L. Knittle, Jules Hirsch, Effect of early nutrition on the development of rat epididymal fat pads: cellularity and metabolism Journal of Clinical Investigation. ,vol. 47, pp. 2091- 2098 ,(1968) , 10.1172/JCI105894
Lester B. Salans, Jerome L. Knittle, Jules Hirsch, The role of adipose cell size and adipose tissue insulin sensitivity in the carbohydrate intolerance of human obesity Journal of Clinical Investigation. ,vol. 47, pp. 153- 165 ,(1968) , 10.1172/JCI105705
M P Czech, Cellular basis of insulin insensitivity in large rat adipocytes. Journal of Clinical Investigation. ,vol. 57, pp. 1523- 1532 ,(1976) , 10.1172/JCI108422
SAUL M. GENUTH, Plasma insulin and glucose profiles in normal, obese, and diabetic persons. Annals of Internal Medicine. ,vol. 79, pp. 812- 822 ,(1973) , 10.7326/0003-4819-79-6-812