The control of sodium metabolism to maintain osmo- and volumehomeostasis.

摘要: Chronically instrumented female beagles were maintained in standardized environmental and dietary conditions allowing careful examination of the mechanisms governing sodium homeostasis. The experimental increase left atrial pressure (obtained by a reversible mitral stenosis) is accompanied an excretion (atrial natriuresis, AN). AN served as manoeuvre from which homeostasis could be elucidated. results allow following conclusions: (1) ‘signals’ arising distension atrium (e.g. expansion extracellular fluid volume) appear not to necessary prerequisite for maintenance (2) control seem very sensitive changes total body (TBS). A small reduction TBS abolishes eliminating processes e.g. saline diuresis, osmotic AN. (3) It probable that natriuretic factor exists elimination. In summary, appears controlled series ‘redundant’ guarantee appropriate strategy comfort ultimate survival organism. At moment it impossible quantitate contributions made various metabolism.