Understanding subfertility at a molecular level in the female through the application of nuclear magnetic resonance (NMR) spectroscopy

摘要: background: Understanding the aetiology of subfertility and female reproductive tract disorders at a molecular level may improve success rates in fertility treatment. Such understanding be gained by application metabonomics technologies to tissues or biofluids. Metabo- nomics is concerned with quantification molecules metabolome uses nuclear magnetic resonance (NMR) spectroscopy as one main technological platforms. This review concentrates on NMR studies discusses further possible appli- cations. While full metabolic profiling relatively recent, targeted biofluid tissue has longer history. methods: Searches were carried out MEDLINE w , PubMed, SciFinder Scholar 2007 ISI Web Knowledge SM for papers about subfertility. results: been employed compositional analysis various elements tract, includ- ing cervical mucus, follicular fluid (FF), ovarian tissue, fallopian tubes uterine matter. was used document first time change FF lipoprotein concentration during development. granulosa cells from rats revealed that follicle-stimulating hormone increases activity pentose pathway, having crucial implications stimulation regimens. In matter work, it shown glycolysis rapidly stimulated estrogen, another study, citrate found potential biomarker adenomyosis. also show chlamydiae are able achieve higher energy reserves stimulating glucose transport host cells. conclusions: A range spectroscopic techniques have applied however great remains studies. Incorporation into research valuable predicting outcomes assisted conception treatments.