Regulation of progesterone and prostaglandin F2α production in the CL

摘要: Abstract After the luteinizing hormone (LH) surge, cells that remain from ovulated follicle undergo a process of differentiation termed luteinization. Two key features after luteinization are capacity for tremendous production progesterone [10 16 molecules per (min/(g CL))] and to regression or death at appropriate time. There two steroidogenic cell types, small large luteal regulated by different mechanisms. In cells, is stimulated LH through protein kinase A (PKA) pathway. The ruminants produce quantities independent stimulation. Although luteotrophins clearly regulate function, much in some species appears be constitutive, consistent with autonomous aspects cell. step regulation transport cholesterol inner mitochondrial membrane apparently mediated acute regulatory (StAR). addition, our recent research indicates PKA tonically active this may responsible high, relatively nature production. Regression corpus luteum (CL) many initiated prostaglandin (PG) F 2α secreted uterus. Luteal also have PGF . can variety substances including inhibition stimulation cytokines. We characterized positive feedback pathway ruminant porcine CL which amounts uterine stimulate intraluteal due induction cycloxygenase-2 (Cox-2) enzyme cells. This only present has acquired (∼day 7 cow, ∼day 13 pig). Regulation C (PKC) transcriptional factors interacting an E-box 5′ flanking region Cox-2 gene critical element involved Thus, change specific transcription such becomes luteotrophic synthesis induced second messenger pathways activated