Acute toxication of deltamethrin results in activation of iNOS, 8-OHdG and up-regulation of caspase 3, iNOS gene expression in common carp (Cyprinus carpio L.)
作者： Harun Arslan , Serdar Altun , Selçuk Özdemir
DOI: 10.1016/J.AQUATOX.2017.03.014
关键词:
摘要: Abstract Deltamethrin is a widely used synthetic pyrethroid pesticide that protects agricultural yields, including crops, fruits, and vegetables from insect-pests. It known deltamethrin toxication leads to metabolic disorders has detrimental effects on the brain liver in different organisms. However, harmful of aquatic animals remain unclear. In present study, we aimed evaluate adverse by performing histopathological examination, an immunofluorescence assay, qRT-PCR common carp. We observed low-dose (0.04 μM) high-dose (0.08 μM) exposure caused lamellar cells hyperplasia inflammatory infiltration gills, hyperemia, diffuse hydropic degenerations focal necrosis hepatocytes, necrotic changes neurons, also induced activation inducible Nitric Oxide Synthase (iNOS) 8-hydroxy-2-deoxyguanosine (8-OHdG) liver, depending time (24 h, 48 h, 72 h 96 h). addition, up-regulation caspase-3 gene expression dose (0.04 μM 0.08 μM) (p
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