Serum leptin is increased in growth hormone—deficient adults: Relation to body composition and effects of placebo-controlled growth hormone therapy for 1 year

摘要: The gene product from the ob gene, leptin, has recently been characterized in humans. circulating level of leptin is related to body mass index (BMI) and more closely estimates total fat, whereas visceral fat reported be minor importance. However, it unknown if directly regulated by hormones that influence substrate metabolism composition. We studied adult growth hormone (GH)-deficient (GHD) patients substituted with GH treatment for 12 months a parallel double-blind, placebo-controlled study. Twenty-seven GHD adults age 44.9 ± 1.9 years underwent anthropometric measurements determinaton regional (BMI, waist hip ratio [WHR], computed tomographic [CT] scan, dual-energy x-ray absorptiometry [DEXA] bioimpedance analysis [BIA]) before after substitution (2 IU/m2) design. same were performed 42 healthy aged 39.1 1.7 years. logarithm serum levels correlated positively abdominal subcutaneous (BIA DEXA) untreated subjects. Fasting insulin did not correlate either groups. After administration, composition was significantly changed respect marked decrease fat. relations maintained, furthermore BMI fasting insulin. In multiple linear regression analyses, additional adiposity (intraabdominal maximal anterior-posterio diameter determined CT scan) significant determinants increase during negatively reduction (r = −.825, P .003). At baseline, increased compared controls both sexes (women, 21.8 3.3 v 11.3 1.4 ng/mL, .002; men, 8.1 1.2 4.7 0.7 .008). Leptin similar treated women men 15.9 2.3 .163; 7.1 2.8 .759). patients, higher than (11.3 < .001; .001). Gender remained determinant several models also including age, estradiol levels, insulin, conclude but differently normal subjects, are this relationship maintained due substitution.