Ten years of pneumococcal‐associated haemolytic uraemic syndrome in New Zealand children

摘要: Aim:  To describe the epidemiology, clinical features, management and outcome of pneumococcal-associated haemolytic-uraemic syndrome (P-HUS) in New Zealand over past decade. Methods:  A retrospective chart review children with P-HUS from 1998 to 2007 that were prospectively reported Paediatric Surveillance Unit. was defined as microangiopathic haemolytic anaemia (Hb <100 g/L fragmented red blood cells), thrombocytopaenia (platelet count <130 × 109/L), acute renal impairment oliguria elevated plasma creatinine, confirmed or suspected pneumococcal infection. Results:  Eleven (nine male, two female), predominately Maori Polynesian (10 children) studied. The median age 8.5 months. duration hospitalisation 25 days. Of infections, 10 (six pneumonia, four meningitis) one pneumonia (culture negative, however T activation positive). Nine patients required dialysis for a 13 days. One child meningitis died after therapy withdrawn because severe neurological injury. patient developed end stage kidney disease further had evidence persisting sequelae at follow-up. Conclusions:  Pneumococcal remains an important public health problem children, particularly those Pacific Island ethnicity. should be considered associated haematological abnormalities. These monitored long-term, they are risk permanent