A diet enriched with mackerel (Scomber scombrus)-derived products improves the endothelial function in a senior population (Prevención de las Enfermedades Cardiovasculares: Estudio Santoña - PECES project).

摘要: Background  Regular consumption of fish reduces cardiovascular risks. Here, we investigate if the products with mackerel (Scomber scombrus) 8·82 g eicosapentaenoic acid (EPA) + docosahexaenoic (DHA) content per 100 g product improves parameters endothelial function in a controlled population. Materials and methods  Subjects maintained 12-week diet mackerel. The population consisted 58 senior subjects (12 withdrawals, 25 women), aged 82·08 ± 8·13 years (Group A). Twenty-three (13 women) on regular were used as control group B). Subjects Group A received 57 portions throughout 12 weeks (four to five week mean EPA + DHA 2·5 g day). continuous follow-up final evaluation performed determine level consumption. Plasma samples stored at –70 °C for biochemical study. Endothelial was analysed by reactive hyperemia mercury strain gauge plethysmography measurement blood flow forearm, both baseline end diet. Results  Endothelium-dependent vasodilatation significantly increased (P < 0·001). No changes found B. subgroup analyses showed that improvements produced without disease Nitrites/nitrates von Willebrand factor plasma concentrations higher participants after diet. Conclusions  meat endothelium-dependent, flow-mediated population. This finding might explain some cardioprotective effects