Relation Between Amygdala Structure and Function in Adolescents With Bipolar Disorder

摘要: Abstract Objective Previous study supports the presence of reduced volume and elevated response to emotional stimuli in amygdala adolescents with bipolar disorder (BD). In present study, structural functional magnetic resonance imaging scans were obtained during same neuroimaging session examine structure-function relations BD. We hypothesized that would be inversely associated stimuli, such BD participants smallest volumes exhibit highest response. Method Fifty-one (21 I 30 control adolescents, ages 10-18 years) underwent scans. Amygdala ( n = 49) signal change 44) face processing compared between groups, correlations examined within group 16). Results Adolescents showed decreased p .009) increased faces .043). There was no significant interaction diagnosis emotion type. A inverse association activation observed r −0.54, .029). Conclusions Decreased are consistent previous reports. This represents first report, our knowledge, two findings adolescent sample an relation characterized by stimuli. preliminary finding requires replication suggests a possible pathophysiological link abnormalities structure J. Am. Acad. Child Adolesc. Psychiatry ,2009;48(6):636-642.