Variations in time of serum pancreatic enzyme levels in chronic pancreatitis and clinical course of the disease

摘要: Thirty-four patients with chronic calcified pancreatitis were evaluated clinically and biochemically (at a time when painful relapses not present) every 9 mo for 3 yr; 25 of them also studied at 4 yr. Serum elastase-1, trypsin, lipase, amylase in the same sera measured each visit; levels on entry variations during study compared clinical functional data patients. On entry, low elastase-1 found 11.7% patients, high 41.1%; contrast, trypsin lipase only small number (5.8 11.7%, respectively), whereas present substantial (47.8 32.3% respectively). Over time, we significant (p = 0.000002) reduction levels. Such was or amylase. The serum significantly (p< 0.003) more frequent presenting than stable increased attack rate; this association weaker (p<0.05) absent No correlation between circulating enzymes either alcohol consumption age In severe exocrine impairment, elastase 20% cases, reduced 73.3 53.3% respectively. conclusion, is sampled absence relapses, are often low, mainly presence impairment; mirrors frequency relapses.