BRAF-Directed Therapy in Metastatic Colorectal Cancer
作者： Krittiya Korphaisarn , Scott Kopetz
DOI: 10.1097/PPO.0000000000000189
关键词:
摘要: Activating BRAF (V-raf murine sarcoma viral oncogene homolog B) mutations occur in approximately 5% to 10% of patients with metastatic colorectal cancer, mostly V600E mutation, and it is associated distinct clinical pathological features. To date, there are no approved treatments target this mutation. inhibitor monotherapy has limited efficacy, contrast melanoma. Combination strategies that block not only mutated kinase but other alternative pathways ongoing have demonstrated improved activity. This review aims provide data about new gene mutation cancer.
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