Papillomavirus and disease in humans and animals.
作者： M. S. Campo
DOI: 10.1046/J.1476-5829.2003.00001.X
关键词:
摘要: Papillomavirus (PV) induces exophytic lesions (papillomas, warts) and flat (flat warts, cervical intraepithelial neoplasia) in cutaneous mucosal epithelia. The are usually benign generally regress without eliciting any serious clinical problems a host but occasionally persist. Persistent can be debilitating also provide focus for malignant transformation to squamous cell carcinoma, particularly the presence of environmental or genetic cofactors. This has been experimentally demonstrated animals, cattle, where bovine PV (BPV)-induced papillomas progress cancer upper gastrointestinal (GI) tract urinary bladder animals exposed bracken fern pasture, rabbits, progression skin carcinoma depends on particular variant cottontail rabbit (CRPV) major histocompatibility complex (MHC) class II haplotype animal. In this review, various aspects biology BPV CRPV described compared with those human PV, including viral genome structure, regulation transcription oncogenes, function oncoproteins, co-operation between virus cofactors, latency, immunity vaccination.
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