Association between antiphospholipid antibodies and recurrent fetal loss in women without autoimmune disease: a metaanalysis.
作者： Michéle David , Susan R Kahn , Evelyne Rey , Ian Shrier , Lucie Opatrny
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摘要: OBJECTIVE: To assess the strength of association between recurrent fetal loss (RFL) and presence antiphospholipid antibodies (aPL) in women without autoimmune disease, to examine whether magnitude varies according type or titer antibody timing loss. METHODS: We searched Medline Current Contents for articles published 1975 2003 with terms denoting early (less than 13 weeks) late 24 RFL associated various aPL. Published case-control, cohort, cross-sectional studies rated moderate strong were included our metaanalysis. Pooled odds ratios 95% CI generated using random-effects models Cochrane Review Manager software. RESULTS: Our analysis 25 studies. Lupus anticoagulant (LAC) was (OR 7.79, 2.30-26.45); LAC stronger that any other IgG anticardiolipin (aCL), when combining all titers, both 3.56, 1.48-8.59) 3.57, 2.26-5.65). Restricting include only high titers increased 4.68, 2.96-7.40). It not possible extract data on isolated low aCL positivity. IgM 5.61, 1.26-25.03). There no found anti-Beta2-glycoprotein I 2.12, 0.69-6.53). CONCLUSION: The aPL More relationship as well would be useful. place testing remains determined.
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