Study of high deprenyl dose on the preimplantation embryo development and lymphocyte DNA in rat.
作者： Mareková M , Mihalik J , Kravcuková P , Spakovská T , Schmidtová K
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摘要: To investigate the role of potent MAO-B inhibitor deprenyl in fertilized females, we have evaluated effect chronic treatment with at a high dosage on preimplantation embryo development and DNA damage blood lymphocytes Wistar rats. We found that number embryos isolated from both uterus oviduct per rat was significantly lower experimental group. Almost 14% animals were flushed oviducts compared to 1.95% those control Morphological analysis deprenyl-treated had revealed impaired rates distribution pattern controls. But administration no significant mean cells morulae or even blastocysts. On other hand, cell blastocysts using chi-square test indicated decreased proliferation Despite harmful impact development, as scored employing Comet Assay. Our description adverse effects protective lymphocyte is very important because still widely used human medicine treatment. Potential mechanisms mediating deprenyl-induced are proposed.
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