Individual antigenic specificity of immunoglobulins.

摘要: Publisher Summary This chapter focuses on the existence of idiotypic determinants that are useful in pursuing investigations related to structure and biosynthesis antibodies. As defined, idiotypy applies recognized by an antiserum prepared same species term, individually specific antigenic determinant, is generally used with reference defined a heterologous species, such as rabbit directed purified human antibody or myeloma protein. The original definitions idiotype determinant do not specifically consider cross-reactions. In estimation, discovery cross-reactions identity among immunoglobulins from different donors would compromise usefulness these terms might be qualified accordingly. A contribution constant region possible, but differences proteins must reflect variable regions. It may noted isotypic allotypic similarly particular amino acid sequences, which many instances have been defined.