Glycation & the RAGE axis: targeting signal transduction through DIAPH1.

作者: Alexander Shekhtman , Ravichandran Ramasamy , Ann Marie Schmidt

DOI: 10.1080/14789450.2017.1271719

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摘要: ABSTRACTIntroduction: The consequences of chronic disease are vast and unremitting; hence, understanding the pathogenic mechanisms mediating such disorders holds promise to identify therapeutics diminish consequences. ligands receptor for advanced glycation end products (RAGE) accumulate in diseases, particularly those characterized by inflammation metabolic dysfunction. Although first discovered reported as a (AGEs), expansion repertoire RAGE implicates diverse milieus, autoimmunity, inflammation, obesity, diabetes, neurodegeneration.Areas covered: This review summarizes current knowledge regarding ligand families data from human subjects animal models on role axis diseases. recent discovery that cytoplasmic domain binds formin homology 1 (FH1) domain, DIAPH1, this interaction is essential f...

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