Bleeding, transfusion and the risk of stroke after coronary surgery: A prospective cohort study of 2357 patients

摘要: INTRODUCTION: This study was planned to investigate the impact of severe bleeding and blood transfusion on development stroke after coronary surgery. METHODS: cohort includes 2357 patients undergoing isolated CABG from prospective European Coronary Artery Bypass Grafting (E-CABG) registry. Severity categorized according Universal Definition Perioperative Bleeding (UDPB), E-CABG PLATO definitions. RESULTS: Thirty (1.3%) suffered postoperative stroke. The amount transfused red cell (RBC) (OR 1.10, 95%CI 1.03-1.18), preoperative use unfractioned heparin 4.49, 1.91-10.60), emergency operation 3.97, 1.47-10.74), diseased ascending aorta 4.62, 1.37-15.65) cardiopulmonary bypass (p = 0.043, OR 4.85, 1.05-22.36) were independent predictors Adjusted analysis showed that UDPB classes 3-4 (crude rate: 3.6% vs. 1.0%; adjusted 2.66, 1.05-6.73), grades 2-3 (crudes 6.3% 0.9%; 5.91, 2.43-14.36), life-threatening 2.5% 0.6%, 3.70, 1.59-8.64) associated with an increased risk compared no or moderate bleeding. CONCLUSIONS: are CABG, which is highest in bleeding.