Chronic myelomonocytic leukemia with t (3; 9) (p21; p13) as a sole abnormal appearance: One case report

摘要: Chronic myelomonocytic leukemia, (CMML) is a clinically rare chronic myeloid with an incidence rate of about 1-2/ 100,000/year, and the age predominant cases over 60 years. The median onset 65-70 years, ratio between male female 1.5 : 3.1. Specifi c etiological factors disease are not clear, but may be associated exposure to ionizing radiation, occupational environmental carcinogens, or toxins. FAB (French-American-British) Cooperative Group defi ned CMML as subtype myelodysplastic syndrome (MDS)[1]. Since it has both characters bone marrow abnormal proliferation dysplasia, recently, classified into myelodysplastic/myeloproliferative diseases (MDS/MPD)[2,3], based on classifi cation neoplastic hematopoietic lymphoid tissue. malignant-clone disease, which involves stem cells, no specifi chromosomal abnormalities involved. most common +8, -7/7q-, structural abnormality 12p. found in t (3; 9) (p21; p13) very hematologic malignancy. So far, only 1 case acute lymphoblastic leukemia (ALL) been reported China abroad[4]. A patient genetic at was admitted treated our hospital. follows literature review.