Targeting the growth factors and angiogenesis pathways: Small molecules in solid tumors

摘要: Research over the last decades has provided us with a better understanding of biology solid tumors. In some tumor malignancies single molecular events leading to malignant transformation have been identified, whilst in others multiple pathways seem play role simultaneously. The delineation such led identification therapeutic targets. Multiple compounds are available now treat those aberrations. With wider use newer biologic therapies, characteristics predicting clinical response broadened. This review focuses on management gastrointestinal stromal tumors as well hepatocellular, non small cell lung, renal and breast cancer molecule tyrosine kinase inhibitors, integrating advances monoclonal antibody therapies malignancies. It highlights recent relevant biomarkers predict efficacy elaborates their relevance patients J. Surg. Oncol. 2011;103:574–586. © 2011 Wiley-Liss, Inc.