Prognostic Significance of Platelet-to-Lymphocyte Ratio in Cholangiocarcinoma: A Meta-Analysis.
作者： Gang Hu , Qin Liu , Jian-ying Ma , Cheng-yuan Liu
DOI: 10.1155/2018/7375169
关键词:
摘要: Introduction. Pretreatment platelet-to-lymphocyte ratio (PLR) has been considered a prognostic factor in various cancers. However, the application of PLR assessment patients with cholangiocarcinoma remains controversial. This study aimed to evaluate value pretreatment cholangiocarcinoma. Methods. A systematic search was performed MEDLINE, EMBASE, and Cochrane Library identify studies assessing significance Three databases were searched from inception August 5, 2018. The primary outcome overall survival (OS), secondary outcomes recurrence-free (RFS) progression-free (PFS). Pooled hazard ratios (HRs) or odds (ORs) 95% confidence intervals (CIs) calculated using random-effects models. Results. total 9 including 2395 finally enrolled meta-analysis based on inclusion exclusion criteria. All included retrospective observational cohorts. Elevated predicted poor OS (HR: 1.38, CI: 1.19-1.62, P < 0.001) RFS PFS (HR = 1.55; CI 1.27-1.88; 0.001). Moreover, elevated highly associated male sex (male versus female OR 0.59, 0.44-0.80, R1 resection margin (OR 2.09, 1.24-3.54, 0.006). Conclusion. present demonstrated that might serve as useful biomarker
hindawi.com参考文章(35)
Shishir K. Maithel, T. Clark Gamblin, Ihab Kamel, Celia Pamela Corona-Villalobos, Melanie Thomas, Timothy M. Pawlik, Multidisciplinary approaches to intrahepatic cholangiocarcinoma Cancer. ,vol. 119, pp. 3929- 3942 ,(2013) , 10.1002/CNCR.28312
Norbert Meidenbauer, Jonas T. Johnson, Theresa L. Whiteside, William Gooding, Takashi Tsukihiro, Grzegorz Dworacki, Thomas K. Hoffmann, Spontaneous apoptosis of circulating T lymphocytes in patients with head and neck cancer and its clinical importance. Clinical Cancer Research. ,vol. 8, pp. 2553- 2562 ,(2002)
Bernd Echtenacher, Daniela N. Männel, Michael Hafner, Bernhard Nieswandt, Lysis of Tumor Cells by Natural Killer Cells in Mice Is Impeded by Platelets Cancer Research. ,vol. 59, pp. 1295- 1300 ,(1999)
Beyhan Yılmaz, Engin Şengül, Aylin Gül, Ulaş Alabalık, Fazıl Emre Özkurt, Mehmet Akdağ, İsmail Topçu, Neutrophil–Lymphocyte Ratio as a Prognostic Factor in Laryngeal Carcinoma Indian Journal of Otolaryngology and Head & Neck Surgery. ,vol. 70, pp. 175- 179 ,(2018) , 10.1007/S12070-014-0769-4
Kang-jie Chen, Lin Zhou, Hai-yang Xie, Taki-Eldin Ahmed, Xiao-wen Feng, Shu-sen Zheng, Intratumoral regulatory T cells alone or in combination with cytotoxic T cells predict prognosis of hepatocellular carcinoma after resection Medical Oncology. ,vol. 29, pp. 1817- 1826 ,(2012) , 10.1007/S12032-011-0006-X
Jia Zhou, Tong Ding, Weidong Pan, Ling-yan Zhu, Lian Li, Limin Zheng, Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients. International Journal of Cancer. ,vol. 125, pp. 1640- 1648 ,(2009) , 10.1002/IJC.24556
Joseph S. Palumbo, Jay L. Degen, Mechanisms coupling the hemostatic system to colitis-associated cancer Thrombosis Research. ,vol. 125, pp. S39- S43 ,(2010) , 10.1016/S0049-3848(10)70011-6
T. A. Zikos, A. D. Donnenberg, R. J. Landreneau, J. D. Luketich, V. S. Donnenberg, Lung T-cell subset composition at the time of surgical resection is a prognostic indicator in non-small cell lung cancer Cancer Immunology, Immunotherapy. ,vol. 60, pp. 819- 827 ,(2011) , 10.1007/S00262-011-0996-4
Mahesh K. B. Parmar, Valter Torri, Lesley Stewart, Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Statistics in Medicine. ,vol. 17, pp. 2815- 2834 ,(1998) , 10.1002/(SICI)1097-0258(19981230)17:24<2815::AID-SIM110>3.0.CO;2-8
A Tuomisto, K Klintrup, J Mäkelä, T J Karttunen, M J Mäkinen, J P Väyrynen, Detailed analysis of inflammatory cell infiltration in colorectal cancer British Journal of Cancer. ,vol. 109, pp. 1839- 1847 ,(2013) , 10.1038/BJC.2013.508