Oligomerization and toxicity of Aβ fusion proteins.
作者： Joanne M. Caine , Prashant R. Bharadwaj , Sonia E. Sankovich , Giuseppe D. Ciccotosto , Victor A. Streltsov
DOI: 10.1016/J.BBRC.2011.05.029
关键词:
摘要: This study has found that the Maltose binding protein Aβ42 fusion (MBP-Aβ42) forms soluble oligomers while shorter MBP-Aβ16 and control MBP did not. MBP-Aβ42, but neither nor MBP, was toxic in a dose-dependent manner both yeast primary cortical neuronal cells. demonstrates potential utility of MBP-Aβ42 as reagent for drug screening assays cell cultures candidate further characterization.
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