The role of motor proteins in endosomal sorting.
作者： Sylvie D. Hunt , David J. Stephens
DOI: 10.1042/BST0391179
关键词:
摘要: Microtubule motor proteins play key roles in the spatial organization of intracellular organelles as well transfer material between them. This is illustrated both by vectorial biosynthetic cargo from endoplasmic reticulum to Golgi apparatus sorting secretory and endocytic endosomal system. Roles have been described for dynein kinesin motors each these steps. Cytoplasmic a highly complex comprising multiple subunits that provide functional specialization. The family human kinesins includes over 40 members. complexity provides immense diversity, yet little known specific requirements functions individual during discrete membrane trafficking In present paper, we describe some latest findings this area seek define mechanisms recruitment control activity microtubule through network.
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